Milk Thistle – Silybum Marianum

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Milk Thistle: Scientific Evidence

Randomized Clinical Trials (RCTs) are considered the highest form of scientific evidence.  A group of people with the same condition are divided into two groups, and randomly assigned to receive the medicine or a placebo.  Neither the patient nor the doctors know which group they are in until the results are assessed.

The following are RCTs in the National Library of Medicine listed when you search “Silymarin double blind.”

Phytotherapy Res. Aug 2020.  The results showed that S. marianum can decrease frequency and severity of hot flashes significantly in Menopause. (1)

Phytotherapy Res. Feb 2019.  Results: Prophylactic administration of silymarin gel could significantly reduce the severity of radiodermatitis and delay its occurrence after 5 weeks of application. (2)

Radiodermatitis is being burned by radiation from your doctors care.

J Evid Based Complementary Altern Med Oct 2017.  Results: The mean serum fasting blood glucose, glycosylated hemoglobin (overall blood sugar control), and triglyceride in the herbal drug group were significantly less than placebo group’s values after 3 months of the intervention, in Diabetic patients.  The “drug” was Milk Thistle, Stinging Nettle, and Frankincense. (3)

J Biol Regul Homeost Agents Jun 2017.  Results: 136 obese subjects with T2DM (Diabetes) and metabolic syndrome were analyzed for fasting blood glucose and insulin, Insulin Resistance, total, HDL and LDL cholesterol, triglycerides, uric acid, BMI, waist circumference, waist to hip ratio and underwent bioelectrical impedance to assess % of abdominal fat. All the above-mentioned parameters, as recorded at enrollment, after 6 months and at the end of the study, had significantly improved in the Milk Thistle / Barberry-treated group in respect to baseline and to the control group. A validated national cardiovascular risk score also improved significantly after treatment in respect to placebo. Our results point to a clinically significant effect in obese people with T2DM and metabolic syndrome. Moreover, for the first time, they provide evidence of a significant uric acid lowering activity as an additive beneficial effect of Milk Thistle / Barberry. (4)

True HM Detox is our product with Milk Thistle and Barberry.

Phytotherapy Res. Nov 2016.  Results: Prophylactic administration of silymarin tablets significantly reduced the severity of radiotherapy induced mucositis and delay its occurrence in patients with head and neck cancer. (5). Proven to reduce the severity of the harm caused by your doctor.

Clin Nutr. Oct 2016. Conclusions: The addition of B. aristata/S. marianum to insulin therapy in patients with type 1 diabetes mellitus leads to a reduction of the insulin dose necessary to have an adequate glycemic control. (6)

Phytomedicine Feb 2015.  Results: fasting plasma glucose, insulin, and HOMA-index levels (Insulin Resistance) were reduced by Milk Thistle / Barberry, but not by placebo. (7)

J Biol Regul Homeost Agents Jun 2014.  Results:  a combination of red yeast rice, Silybum marianum and octasonol was effective in improving lipid profile, endothelial, and inflammatory parameters in dislipidemic patients. (8)

Phytomedicine Dec 2013.  Results: Use of selenium-silymarin mix reduces lower urinary tract symptoms and prostate specific antigen in men. (9)

Eur J Haematol Mar 2013.  Results: Serum ferritin levels decreased significantly from the beginning to the end of silymarin treatment in patients with Thalassemia. (10)

Biomed Pap Med Fac Univ Palacky Olomouc Czech Republic. Sep 2010.  Results: This suggests that Milk Thistle and Selenium may be effective in reducing Prostate Cancer progression. (11)

Prog Neuropsychopharmacol Biol Psychiatry Mar 2010.  Results: Milk Thistle worked just as well as Prozac in the treatment of OCD. (12)

Cancer Jan 2010. Conclusions: In children with acute lymphoblastic leukemia (ALL) and liver toxicity, Milk Thistle (MT) was associated with a trend toward significant reductions in liver toxicity. MT did not antagonize the effects of chemotherapy agents used for the treatment of ALL. (13)

Again, Plant Medicine protecting patients from the damage of Modern Medicine.

J Clin Pharmacol Ap 2010.  Results: Silymarin has been shown to decrease the complications of liver disease and mortality in patients with cirrhotic disease, and is safe at higher than normal doses.  (14)

Transpl Int. Jul 2014.  Results: Milk Thistle has a significant antiviral activity in patients with established HCV (Hepatitis C). (15)

BMC Dermatol Oct 2012. Conclusions: Silymarin showed tremendous improvement of melasma (brown spots on skin) in a dose-dependent manner, and was effective in prevention of skin damage caused by U.V. sunlight. (16)

Chin J Integr Med Dec 2015.  Results: Disease Activity Index significantly decreased in the silymarin group in patients with Ulcerative Colitis. (17)

Free Radic Biol Med May 2012.  Results: In patients with Fatty Liver, Treatment with Silymarin and PhosphatidylCholine but not Placebo for 12 months was associated with improvement in liver enzymes, insulin resistance, and liver histology (tissue health). (18)

Otolaryngol Head Neck Surg. Dec 2011.  Conclusion: Considering the statistically effective role of silymarin in alleviating the severity of allergic rhinitis symptoms, applying this herbal antioxidant along with other medications may result in better management. (19)

Phytomedicine May 2009.  Results: No adverse events were noted and both silymarin and placebo were well tolerated. Patients randomized to the silymarin group had quicker resolution of symptoms related to Acute Hepatitis. Biliary retention: dark urine, jaundice and scleral icterus. (yellow eyes). (20)

J Cosmet Dermatol. Mar 2008. Conclusions: The combination of silymarin and MSM can be useful in managing symptoms and condition of rosacea skin, especially in the rosacea subtype 1 erythemato-telangiectatic phase. (21)

Phytother Res Dec 2006.  Results: The results showed a significant decrease in HbA1c (overall blood sugar regulation), Fasting Blood Sugar, total cholesterol, LDL, triglyceride SGOT and SGPT levels (Liver function) in silymarin treated patients compared with placebo as well as with values at the beginning of the study in each group. In conclusion, silymarin treatment in type II diabetic patients for 4 months has a beneficial effect on improving the glycemic profile. (22)

True Health offers True HM Detox, featuring Milk Thistle, in our online store!

-DrStone

 

Turmeric – Curcuma Longa

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Turmeric: Scientific Evidence

Randomized Clinical Trials (RCTs) are considered the highest form of scientific evidence.  A group of people with the same condition are divided into two groups, and randomly assigned to receive the medicine or a placebo.  Neither the patient nor the doctors know which group they are in until the results are assessed.

The following are RCTs in the National Library of Medicine listed when you search “Turmeric double blind.”

Nutrients Jun 2020.  Results: Compared with placebo, curcumin was associated with several significant effects. These included better working memory performance at 12-weeks, and lower fatigue scores on the Profile of Mood States (POMS), and of tension, anger, confusion and total mood disturbance. (1)

Eur J Appl Physiol. Jul 2020. Conclusion: Curcuma longa L. extract supplementation leads to a decrease in inflammation and muscle break down in recreational male runners after a half-marathon race. (2)

Clin Nutr. Mar 2020. Conclusion: Three months treatment with curcumin in Chronic Kidney Disease patients resulted in decreased markers of inflammation, suggesting that oral supplementation of curcumin have an anti-inflammatory effect in this patient group. (3)

Diabetes Metab Syndr Obes Mar 2020: Conclusion: A nutraceutical containing Berberine, Curcumin, Inositol, Banaba, and Chromium Picolinate can be helpful in improving glyco-metabolic compensation, Cholesterol and Triglyceride value, and in reducing inflammatory status in patients with dysglycemia. (4)

Phytotherapy Res Aug 2020. The results of this study indicated that intake of the selected herbs (Ginger, Turmeric, Black Pepper) twice a day for 4 weeks improved the inflammation levels in patients with chronic knee osteoarthritis just as well as Naproxen drug. (5)

Complement Ther Med. Mar 2020.  Conclusions: Curcumin improved Quality of Life in liver cirrhotic patients. (6). Sick patients were able to do more, feel better.  A win!

J Res Med Sci Aug 2019. Conclusion: Our study showed that curcumin was effective therapy for ameliorating protein in the urine (kidney disease) in type 2 diabetic patients. (7)

Nutrients Aug 2019.  Results: The WEC group also showed significant improvement of SF-36 scores (for general health, vitality, mental health, and mental summary component) and POMS scores for positive mood states (vigor-activity and friendliness). (8)

Arthritis Ther Res Jul 2019.  Results: Turmeric significantly decreased knee pain in patients with chronic osteoarthritis over 90 days. (9)

Phytotherapy Res. Jul 2019.  Results: Three months treatment with C. longa significantly decreases arterial stiffness as compared with placebo in type 2 diabetes mellitus patients. (10)

Diabetol Metab Syndr. May 2019. Result: Supplementation with curcumin in type 2 diabetes compare to placebo causes a significant changes in mean weight, body mass index (BMI), waist circumference and fasting blood sugar. (11)

Int J Vitam Nutr Res Nov 2019.  Results: In conclusion, turmeric and chicory seed supplementation can be significantly useful in management of Non-Alcoholic Fatty Liver Disease. (12)

J Ethnopharmacol Jun 2019.  Results: Asthma patients receiving C. longa experienced less frequent nighttime awakenings, less frequent use of short-acting β-adrenergic agonists, and better disease control after 3 and 6 months. (13)

Complement Ther Med. Ap 2019. Conclusion: Our findings indicated that curcumin supplementation for 2 months improved and reduced the severity of Neuropathy in patients with T2Diabetes. (14)

Endocr Metab Immune Disord Drug Targets 2019.  Results: The combination of ω-3 fatty acids and curcumin significantly reduced the frequency, severity and duration of migraine headaches. (15)

Breastfeed Med Nov 2018. Conclusion: Mixed herbal supplementation that contained fenugreek, ginger, and turmeric can increase human milk volume without adverse effects. (16)

J Dermatolog Treat Sep 2019. Conclusions: Curcumin is a safe treatment and can be used to reduce pain, burning sensations, and the clinical appearance of oral lesions in Oral Lichen Planus patients. (17)

J Evid Based Integr Med. Dec 2018.  Results: Turmeric significantly improved the gut microbiota. (18)

Neural Regen Res Jul 2018.  Results: These findings indicate that Zishenpingchan (Traditional Chinese Medicine with Curcumin) granules can mitigate symptoms of Parkinson’s disease, reduce toxic side effects of dopaminergic agents, and exert synergistic and detoxifying effects. (19)

3000 years of practice, and you can even make medicine to effectively treat Parkinsons Disease.

Diabetes Obes Metab. Nov 2018:  Results: At the end of the trial period, the Curcumin, Curry, Moringa supplemented group showed significant reductions in body weight and BMI, compared with placebo. Significant reductions in waist and hip circumferences, and a 2.08-fold reduction of waist/hip ratio, were noted in the supplemented group. Supplementation also resulted in significant improvements in lipid profiles, compared with the placebo; low-density lipoprotein (LDL) cholesterol decreased, while high-density lipoprotein (HDL) cholesterol increased, resulting in a significantly improved LDL/HDL ratio. No major adverse events were reported. (20)

Phytother Res Sep 2018. Results:  Curcumin administration alleviated iron burden and liver dysfunction by reducing Iron, and improving liver enzymes, ALT and AST, in patients with β-thalassemia major. (21)

J Cosmet Dermatol Jun 2018.  Results: Compared to the placebo, turmeric significantly reduced the erythema, scaling and induration of lesions, and also improved the patients’ quality of life in patients with scalp psoriasis. (22)

BMC Complement Altern Med Jan 2018. Conclusions: Twelve-week use of curcumin complex or its combination with boswellic acid reduces pain-related symptoms in patients with OsteoArthritis. (23)

J Med Food Oct 2017. Results: Rheumatoid Arthritis patients who received the curcumin product at both low and high doses reported statistically significant changes in their clinical symptoms at the end of the study. (24)

Complement Ther Med Aug 2017.  Results: Curcumin supplementation could contribute to a reduced risk of cardiovascular events in dyslipidemic patients with T2Diabetes because of its favorable effects on cholesterol and inflammation levels. (25)

J Affect Disord Jan 2017.  Results: Curcumin and Saffron were associated with significantly greater improvements in depressive symptoms compared to placebo, and superior improvements in anxiety scores. (26)

Pak J Pharm Sci Nov 2105.  Results: In summary it is concluded that Turmeric, Pennywort, and Walnut could be used as promising source for treatment of eczema. (27)

West Ind Med J Sep 2015.  Conclusion: Turmeric was effective in faster healing of wounds of Caesarean operation. The use of turmeric is suggested to reduce the complications of the wounds from Caesarean section. (28)

Iran J Pharm Res. 2015.  Results: The clinical and therapeutic benefit of this novel topical formulation was evaluated on 34 patients with mild to moderate plaque psoriasis in a randomized, prospective intra-individual, right-left comparative, placebo-controlled, double-blind clinical trial. The Dermatology Life Quality Index (DLQI) Questionnaire and Psoriasis area & severity index (PASI) score as well as photos before and after treatment was used to evaluate the outcomes. The results show that the clinical and quality of life parameters in treated lesions in comparison with untreated lesions have significantly improved. The reported side effects were also recorded and were trivial. (29)

Complement Ther Med Ap 2015. Conclusion: Turmeric and Black seeds showed improvement in all parameters of metabolic syndrome. (30)

The next study says Turmeric was not effective with Mastitis, but I used Oregon Grape and Red Root for Mastitis and the lady emailed me 3 hours later, saying her pain was gone.

Drug Res. 2015.  Results: Turmeric does protect the lungs from Sufur Mustard gas exposure. ?WTF? (31)

Phytotherapy Res. Oct 2014.  Results: Adjuvant therapy with a bioavailable curcuminoid preparation can significantly improve Quality of Life and suppress systemic inflammation in patients with solid tumors who are under treatment with standard chemotherapy protocols. (32)

J Nephrol. Ap 2014. Conclusions: This study demonstrates the efficacy of turmeric in decreasing inflammation and uremic pruritus (chronic itching that occurs in patients with advanced or end-stage renal disease) in end stage renal disease patients. (33)

J Nutr Biochem Feb 2014.  Results: In summary, a 6-month curcumin intervention in type 2 diabetic population lowered the atherogenic (Stroke/Heart Attack) risks. In addition, the extract helped to improve relevant metabolic profiles in this high-risk population. (34)

Am J Cardiology Jul 2012. It is well established that myocardial infarction (MI) associated with coronary artery bypass grafting (CABG) predicts a poor outcome. Results: In conclusion, we demonstrated that curcumin significantly decreased MI (heart attack) associated with CABG. The antioxidant and anti-inflammatory effects of curcumin may account for their cardioprotective effects shown in this study. (35)

Surg Endosc Dec 2011.  Conclusions: Turmeric (curcumin) improves postoperative pain- and fatigue following Lap.Cholecystectomy (Gall Bladder removal). (36)

Or you can follow DrStones approach, Boldo, Beet Root, and Fish oils SAVED a sick Gall Bladder in a woman scheduled for this surgery.  This approach decreased the pain of scalpels SIGNIFICANTLY.

Altern Med Rev Jun 2011.  Conclusions: Although two small studies have shown promising results, all authors conclude that larger-scale, double-blind trials need to be conducted to establish a role for curcumin in the treatment of ulcerative colitis. (37)

IDK?  If something worked for one person, and had no harmful side effects, why not give it a try?  Or use DrStones approach for Ulcerative Colitis.  Even better.  The person no longer has Ulcerative Colitis.

Turmeric is in our Natural Anti-inflammatory, natural alternative to NSAIDS that works better than any pharmaceutical in side by side testing… True Pain Relief.

Reishi – Ganoderma Lucidum

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Reishi: Scientific Evidence

lewy body dementia

Randomized Clinical Trials (RCTs) are considered the highest form of scientific evidence.  A group of people with the same condition are divided into two groups, and randomly assigned to receive the medicine or a placebo.  Neither the patient nor the doctors know which group they are in until the results are assessed.

The following are RCTs in the National Library of Medicine listed when you search “Ganoderma double blind.”

Int J Med Mushrooms 2018.  Results: Children in the group receiving a yogurt with Reishi presented a significantly higher absolute count of peripheral blood total lymphocytes (CD3+, CD4+, and CD8+ T cells) than that in the group receiving placebo. The interventions were safe and well tolerated. (1)

Pharm Biol. Dec 2017. Discussion and conclusion: The outcome of the present intervention demonstrated the antioxidation, anti-aging and hepatoprotective nature of GL by effectively curbing oxidative stress. (2)

Nutr Hosp. Nov 2015. Results: after the 6-week treatment period, Ganoderma lucidum significantly improved aerobic endurance, lower body flexibility, and velocity in patients with Fibromyalgia. (3)

Phytotherapy Res. Jun 2009. Results:Treatment with Reishi for patients receiving chemotherapy and/or radiotherapy may improve their immune function, improving their ability to fight off the cancer, as well as any secondary infections that could compromise their treatment and their health. (4)

Asian J Androl. Sep 2008.  Conclusion: The extract of G. lucidum was well tolerated and significantly improved Urinary Prostate Symptom scores. (5)

Arthritis Rheum Oct 2007.  Results: Pain score and patient’s global score improved significantly only in the Reishi group. Conclusion: G lucidum (and three other plants) may have analgesic effects for patients with active RA, and were generally safe and well tolerated. (6)

Anesth Analg Aug 2005. Results:The use of Ganoderma lucidum preoperatively is unlikely to increase the risk of surgical bleeding in otherwise healthy patients. (7)

J Med Food 2005.  Results: These findings indicated that Reishi was significantly superior to placebo with respect to the clinical improvement of symptoms in neurasthenia (weariness, fatigue, headache, and irritability, associated chiefly with emotional disturbance). (8)

I’d call that the End Of Your MTHRFing Rope!

That is the end of Human RCTs, but look at the value witnessed with animal testing.  Remember, no danger to try!

Biomed Pharmacother. Aug 2020: Results:  Reishi significantly reduced the damage from our dumb ass medicine (chemotherapy). (9)

Int J Med Mushrooms 2020.  Results: Significantly reduced the kidney damage of another stupid ass medicine (hurtful antibiotic). (10)

Only a stupid man would declare war on disease. LMAO

Am J Transl Res. Jun 2020.  Results: Significantly inhibited tumor weight (colon cancer) and tumor volume.  In summary, GLE has potential to be developed as an anticancer agent against colorectal cancer. (11)

Drug Des Devel Ther. Jun 2020. Purpose: Drug-induced liver injury is the most common cause of acute liver failure.  Results: Reishi significantly decreased the liver damage from our hurtful medicines. (12)

Pharmacology 2020. Conclusions: All of these data illustrated that GLP could alleviate the activity and aggressiveness, block the cell cycle, and promote the apoptosis (destruction) of cervical cancer cells. (13)

Integr Cancer Ther. Dec 2019. Results: G lucidum inhibited the proliferation, migration, and invasion, and induced apoptosis (destruction) of human osteosarcoma. (14)

There are many studies that conclude that Reishi significantly reduces the side effects of Chemo and Radiation, while significantly improving outcomes.  A patient of True Health used True Cancer Fighter with Reishi while being treated, and ALL the side effects were resolved, and her hair grew back!  While receiving Chemo/Radiation!!

Reishi is an ingredient in True Allergy Relief, True Clear Skin, True Energy Boost, True Masculine Strength, and True Tissue Heal, which is our solution for leaky gut!

-DrStone

Rhodiola Rosea

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Rhodiola: Scientific Evidence

adrenal fatigue supplementsRandomized Clinical Trials (RCTs) are considered the highest form of scientific evidence.  A group of people with the same condition are divided into two groups, and randomly assigned to receive the medicine or a placebo.  Neither the patient nor the doctors know which group they are in until the results are assessed.

The following are RCTs in the National Library of Medicine listed when you search “Rhodiola double blind.”

Phytotherapy Res. June 2020.  Results: Show an improvement of mental speed and moreover, suggest improved mental resources. (1)

Pharmaceuticals May 2020. Results: The menopause symptom relief effects of Rhodiola and Black Cohosh were significantly superior in all tests to the effects of Black Cohosh and placebo after their repeated administration for 6 and 12 weeks. (2)

Front Pharmacol Mar 2020.  Results: A total of 18 RCTs involving 1,679 patients were included in the meta-analysis. Adjuvant treatment with Rhodiola significantly decreased ≥80% reduction in the frequency of angina attacks. (3)

J Affect Disord Mar 2020. Conclusions: It is concluded that the Rhodiola capsule shows anti-depressive potency in patients with depression disorder. (4)

Nutrients Oct 2019. Results: Improvement in body composition profiles were significantly greater in the Rhodiola/Cordyceps group (body weight, BMI, upper extremity fat mass, lower extremity muscle mass, trunk fat mass) compared to the placebo group after training. (5)

J Sport Health Sci. Oct 2018. Results: Rhodiola rosea ingestion shortened reaction time and total response time. Moreover, a greater relative increase in the number of correct responses was observed in Rhodiola group as compared to the placebo group. (6)

Phytomedicine June 2016. Conclusions: Rhodiola rosea demonstrates multi-target effects on various levels of the regulation of cell response to stress, affecting various components of the neuroendocrine, neurotransmitter receptor and molecular networks associated with possible beneficial effects on mood. (7)

PLoS One Jun 2015.  Results: Rhodiola tended to protect against acute exacerbation of COPD and significantly improved tidal breathing and ventilation efficiency, in patients with COPD. (8)

Phytomedicine Mar 2015. Conclusions: Although R. rosea produced less antidepressant effect versus sertraline (Zoloft), it also resulted in significantly fewer adverse events and was better tolerated. These findings suggest that R. rosea, although less effective than sertraline, may possess a more favorable risk to benefit ratio for individuals with mild to moderate depression. (9)

Get True Stress Resilience and True Mood Lift, and I bet you experience more antidepressant effect than Zoloft.

High Alt Med Biol. Sept 2004.  Results: After 2 weeks of altitude training, compared with Placebo group, the exhaustive run time was markedly longer and the decline of parasympathetic (PNS) activity was significantly prevented in Rhodiola/Cordyceps group. (10)

Complement Ther Med Aug 2014.  Conclusion: Rhodiola formulations may have a positive effect on treating Ischemic Heart Disease alone and in combination with Routine Western Medicine. (11)

Holistic Nurse Pract Ap 2014.  Results: Rhodiola rosea is found to be effective in the treatment of stress-related fatigue. (12)

J Strength Cond Res. Mar 2013.  Results: Rhodiola rosea ingestion significantly decreased heart rate during the standardized warm-up, and subjects completed the Time Trial significantly faster after R. rosea ingestion. (13)

Phytomedicine Jun 2010.  Results: Showed a significant difference in attention, speed, and accuracy  between the two treatment groups. The subjects in the Rhodiola/Eleuthero/Schizandra group quickly (two hours after ingestion) gained improved attention and increased speed and accuracy during stressful cognitive tasks, in comparison to placebo. There was also a tendency to reduce percentage of errors, which means better accuracy, quality of the work, and degree of care in the volunteers under stressful conditions. (14)

Phytotherapy Res Aug 2009.  Results: After supplementation, a significant decrease concerning the experienced level of fatigue in the Rhodiola group was observed compared with the placebo group. (15)

Rhodiola is an ingredient in True Stress Resilience, True Heart Health, True Fem Vitality, True Addiction Relief, and True Asthma Relief!